GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs9475752 | 1 | rs1451708 | chr6:56802201 | BEND6 | chr6:56819773-56892138:+ | -0.36 | -9.71 | 2.11E-21 | Menarche (age at onset) |
| BRCA | cis | rs9475752 | 1 | rs1451708 | chr6:56802201 | KIAA1586 | chr6:56911384-56920021:+ | -0.18 | -3.65 | 0.000274 | Menarche (age at onset) |
| BRCA | cis | rs1453414 | 1 | rs1453414 | chr11:5829084 | OR56A3 | chr11:5968577-5969522:+ | 0.15 | 3.4 | 0.000704 | Oropharynx cancer;Oral cavity and pharyngeal cancer |
| BRCA | cis | rs1453414 | 1 | rs1453414 | chr11:5829084 | UBQLNL | chr11:5535624-5537956:- | 0.22 | 3.78 | 0.000167 | Oropharynx cancer;Oral cavity and pharyngeal cancer |
| BRCA | cis | rs3796619 | 1 | rs1453605 | chr4:1075771 | CRIPAK | chr4:1385340-1389782:+ | 0.11 | 3.42 | 0.000649 | Recombination rate (males) |
| BRCA | cis | rs3796619 | 1 | rs1453605 | chr4:1075771 | KIAA1530 | chr4:1341104-1381836:+ | 0.11 | 3.65 | 0.00028 | Recombination rate (males) |
| BRCA | cis | rs9876781 | 1 | rs1459242 | chr3:48413537 | ATRIP | chr3:48488141-48507708:+ | -0.1 | -3.52 | 0.000453 | Longevity |
| BRCA | cis | rs9876781 | 1 | rs1459242 | chr3:48413537 | TREX1 | chr3:48501186-48509043:+ | 0.25 | 9.49 | 1.46E-20 | Longevity |
| BRCA | cis | rs9475752 | 1 | rs1460561 | chr6:56797574 | BEND6 | chr6:56819773-56892138:+ | -0.34 | -9.09 | 4.59E-19 | Menarche (age at onset) |
| BRCA | cis | rs9475752 | 1 | rs1460561 | chr6:56797574 | KIAA1586 | chr6:56911384-56920021:+ | -0.17 | -3.41 | 0.000665 | Menarche (age at onset) |
| BRCA | cis | rs4908760 | 1 | rs1463050 | chr1:8597042 | RERE | chr1:8412466-8877699:- | 0.11 | 3.56 | 0.000381 | Vitiligo |
| BRCA | cis | rs4908760 | 1 | rs1463051 | chr1:8596893 | RERE | chr1:8412466-8877699:- | -0.11 | -3.61 | 0.00032 | Vitiligo |
| BRCA | cis | rs1463104 | 1 | rs1463104 | chr4:88799710 | SPP1 | chr4:88896802-88904562:+ | 0.13 | 4.02 | 6.23E-5 | Bone mineral density |
| BRCA | cis | rs718314 | 1 | rs1463679 | chr12:26470169 | BHLHE41 | chr12:26272961-26278003:- | 0.14 | 3.83 | 0.000137 | Waist-hip ratio;Renal cell carcinoma |
| BRCA | cis | rs718314 | 1 | rs1463679 | chr12:26470169 | SSPN | chr12:26348269-26405853:+ | 0.12 | 3.61 | 0.000315 | Waist-hip ratio;Renal cell carcinoma |